AdresBioassay Technology transfer specialist - 2306155831W
Description
In our organization, entrepreneurial people are working in a dynamic culture in which innovation and a ‘can-do’ state of mind are central. To strengthen our team, we are continuously looking for enthusiastic, talented people who have the ambition to develop themselves and can be of value to Janssen.
For our department, we are currently seeking a fulltime
Bioassay Technology transfer specialist – Bacterial Vaccines
Department:
The Bacterial Vaccines (BacVac) department is working on the discovery and early development of novel vaccines for bacterial infectious diseases. It strives to address unmet medical needs, such as bacteremia (sepsis), meningitis, and respiratory tract and nosocomial infections. Our projects at the Bacterial Vaccines department are primarily structured on scientific and technical collaboration with external biotechnology partners (governmental and industrial) that are innovative leaders in their field. This working process includes ‘state of the art’ vaccine discovery, with subsequent in vivo evaluation of these vaccine candidates in animal models for immunogenicity and efficacy. Besides, we establish and optimize manufacturing processes and support the generation of clinical trial material for human clinical studies.
The Bacterial Vaccines department has well-equipped laboratories and the possibility to acquire additional equipment and laboratory space. Janssen’s support departments, such as Vaccine Process & Analytical Development (VPAD) and Quality Control (QC), provide expertise to the Bacterial Vaccines department and its external partners for the development of their prototype vaccines.
Biochemical Assays and Antigenicity Screening group(BAAS)is part of the BacVac Analytical Development team. BAAS is responsible for:
Supporting bioassay-based analytical investigations for the research-grade drug substances, drug products, and reference antigens
Analyzing the quality of drug substances produced by BacVac Process Development team or CROs
Overseeing the contract analytics work performed at collaborators (CROs & academic partners)
Development and implementation of new and innovative Analytical Technology Platforms
Subject-matter experts in: bioassays, potency assays, in-process control assays and immunoassays of proteins and glycoproteins
THE POSITION:
Are you interested in a Senior Associate Scientist / Scientist position in a renowned vaccine development company, and one of the world-leading manufacturers of innovative medicines? We offer you this opportunity in the Bacterial Vaccines department at our global R & D center. As part of an interdisciplinary team, you will get well-founded insights and work on a project with the possibility to bring in your ideas and be proactive in its development. At the Bacterial Vaccines – Analytical Development team, you will work on versatile and exciting challenges in an international working environment. The start is as soon as possible; the duration is one year renewable (core position). Do not hesitate to get into contact if you require additional information. During your work, you will interact with various Bacterial Vaccines teams and Janssen Vaccine support departments. We expect you to perform laboratory work in person.
Your primary responsibilities will be:
As part of an interdisciplinary and international team, you will gain insights into the requirements for the development of characterization assays and the work conducted in analytical laboratories with current challenges and processes.
Chemical modification of bacterial surface molecules
Analysis of antigen-antibody interactions
Analyze carbohydrate-, protein-, or glycoconjugate-based antigens.
Know, implement and improve established tests for carbohydrates, proteins, glycoconjugates, and particle-based vaccines.
Develop new biochemical methods (evaluate LoD, LoQ, accuracy, etc.)
With help from product development specialists, design and implement biochemical assays for in-process control (IPC), product characterization, and product release.
Support CROs to plan, execute, document, and review their work.
Learn new automated workflows to evaluate antigen-antibody interactions.
Planning and leading method transfer of bioassays to partner labs (Janssen internal collaborators and external partners)
Qualifications
Qualifications:
Education:
M.Sc. or B.Sc. with equivalent experience
Biochemical assay specialist
Experience:
Minimal 2-4 years of professional experience (experience at a biotech industry setting is a must).
Experience with Biochemical analysis of carbohydrates, proteins and glycoconjugates.
Knowledge of protein purification methods is desirable
Specific knowledge:
Knowledge of biochemical literature, with emphasis on carbohydrate antigens, biochemical assay development, optimization, and troubleshooting.
Very good knowledge on bacterial cell surface molecules
Hands-on expertise on biochemical analysis of large biomolecules with focus on antigen-antibody interactions
Experience and knowledge on chemical modification of microbial surface components
Significant knowledge on purification and enrichment of large biochemical entities
Familiarity with automated or semi-automated instrumentation, while not required, would be advantageous
Must have: Hands on experience on Biolayer interferometry, automated capillary Western blotting methods, capillary electrophoretic methods, colorimetric assays, ELISA, cell-based assays, labelling of biomolecules. Experience on transferring bioassay methods to partner labs.
Nice to have: SPR, Mesoscale thermophoresis, ITC-based screening of biochemical interactions etc.
Competences:
Problem solver, including thorough hands-on laboratory experiments.
Efficient and clear communication.
Team player.
Leadership: able to manage and monitor work contracted to CROs.
Organize data efficiently (databases) and with data security in mind.
Operate and maintain analytical laboratory equipment.
Safety-conscious.
Language skills: fluent English; fluency in Dutch is a plus
Primary Location Europe/Middle East/Africa-Netherlands-South Holland-Leiden
Organization Janssen Vaccines & Prevention BV (8852)
Job Function Clinical Development & Research - Non-MD
Req ID: 2306155831W
